Easium

Easium

Easium Descriptions:
Easium mainly contain Diazepam. Diazepam is a benzodiazepine derivative and is a safe tranquillizer with anxiolytlc, anticonvulsant and central muscterelaxant actions Intravenous Easium injection is widely used in obstetrics and control of status epileptics.

Easium Mode of Actions:
Diazepam attaches to the specific site on the GABA receptor and potentiates the effect of GABA, which acts by opening chloride ion channels into [SNIFF]

Easium Pharmacokinetics:
Diazepam is absorbed rapidly and . completely after oral administration. Peak Plasma concentration reaches within 15-90 minutes. Mean plasma half-life is 30Hours. Plasma protein binding is 98-99%. Diazepam (Easium) is metabolized in the liver with only traces of the unchanged drug excreted in urine. A very small proportion of the metabolites is excreted through the bile into the intestine and eliminated with the feces. After rectal administration in suppository form diazepam is signiflcantly absorbed and peak concentration reaches within 1.5-2 hours.

Easium Composition:
Easium Tablet: Each Easium Tablet Contain Diazepam BP 5mg
Easium Injection: Each 2ml ampule contains Diazepam BP 10mg
Easium Suppository: Each suppository contains Diazepam BP 10mg

Easium Indications:
Diazepam is indicated for the short-term treatment of-mild to moderate anxiety, agltion, fear, aggressiveness etc. Anxiety reactions caused by stressed conditions, anxiety states with somatic expression, acute alcohol withdrawal, status epilepticus, premedication for surgical procedures, febrile convulsions, Insomnia of hospitalized patients.

Easium Dosage and administration:
Oral: Anxiety: 2 mg thrice daily increased if necessary to 15-30 mg daily in divided doses. Elderly (or debilitated), half of the adult dose. Insomnia associated with anxiety: 5-15 mg at bed time. Child: Night terrors and somnambulism, 1-5 mg at bed time.

IV injection: 1M/slow IV injection (large vein, rate below 5 mg/minote): For severe acute anxiety, control of acute panic attacks, and acute alcohOl withdrawal, 10 mg, repeated if necessary after not less than 4 hours.
Febrile convulsion in children: Slow IV in a dose of 250 mcg/kg, or preferably rectally in solution in a dose of 500 mcglkg (maximum 10 mg). repeated if necessary.

Easium Contralndlcations:
Diazepam is contraindicated in myasthenia gravis, pulmonary insufficiency, respiratory depression and hypersensitivity to bezodiazepine.

Easium Side Effects:
Diazepam is generally well tolerated. Higher doses may cause somnolence, dizziness, light headed ness, confusion and ataxia.

Easium Use In pregnancy and Lactation:
Diazepam and its active metabolites cross the placental barrier and also pass into breast milk. So, it should be avoided if possible during pregnancy and lactation.

Easium Precautions:
Prolonged use and abrupt withdrawal should be avoided. Diazepam should be used with caution in respiratory disease, muscle weakness, history of drug or alcohol abuse, in hepatic or renal impairment.

Easium Drug Interaction:
Concomitant intake with alcohol is not recommended. Sedation may be increased due to concomitant use of neuroleptics (antipsychotics), hypnotics, sedative antihistamines and CNS depressants e.g., general anesthetics, narcotic analgesics or antidepressants. Diazepam clearance is increased by concomitant administration of phonobarbitone and is decreased by administration of cimetidine. Omeprazole and isoniazide inhibit diazepam metabolism.

Easium Overdosage:
Sedation, muscle weakness, profound sleep or paradoxical excitation. In more severe cases symptoms may include ataxia, hypotonia, hypotension, respiratory depression and rarely coma and death.

Easium Storage:
Store in a cool and dry place, protected from light.

Easium Packaging:
Easlum Tablet: Each carton contains 10x20 tablets in blister pack.
Easium Injection: Each carton contains 5x5 ampoules in blister pack.
Easium Suppository: Each carton contains 5x2 suppositories in strip pack.

Easium Manufactured by:

Opsonin Pharma Limited