Nugesic

Nugesic Tablet: Each tablet contains Thiamine Mononitrate (Vitamin B1) BP 100 mg, Pyridoxine Hydrochloride (Vitamin B6) BP 200 mg, Cyanocobalamin (Vitamin B12) BP
200 mcg. .

Phannacology:
Nugesic is a combination of neutropic vitamins eg Thiamine Mononitrate (Vitamin B1),Pyridoxine Hydrochloride (Vitamin B6), Cyanocobalamin (Vitamin B12).These vitamins, for their role as co-enzyme are indispensable factors in the metabolism of the nervous system. Nugesic normalizes the nerve cell metabolism. Nugesic supports the regeneration of nerve fibers and myelin sheath by activation of the metabolism and the natural repair mechanism. The analgesic effect of Nugesic is attributed to an increased availability and/or effectiveness of noradrenaline and 5-hydroxytryptamine acting as inhibitory transmitters in the nociceptive system. High doses of these vitamins administered alone or in combination inhibited nociceptive behavior and depressed the nociceptive activity evoked in single neuron of the dorsal horn of the spinal cord and in the thalamus. Moreover, they were found to enhance the antinociceptive effect of non-opjoid analgesic agents. .

Indication:
Nugesic is indicated for the treatment of following diseases:
Neuropathy, Neuritis, Neuralgia, Cervical Syndrome, Shoulder Arm Syndrome, Lumbago, Sciatica, Myalgia, Intercostal Neuralgia, Trigeminal Neuralgia and Arthritis.
It is also indicated where a deficiency of the relevant vitamins exists.

Dosage and Direction for Use:
Nugesic is tablet may be administered in a dose of 1 to 3 tablets daily or as directed by the physician.

Side Effect:
Nugesic is generally well tolerated. In rare cases few allergic responses may be seen.

Precaution:
Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin is not a suitable form of Vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of Cyanocobalamin.

Contraindication:
Nugesic should not be used in patients on Levodopa therapy or hypersensitivity to any of the active ingredients.

Use in Pregnancy & lactation:
Sufficient data yet not available in this respect.

Drug Interaction:
No drug interactions have yet been reported.

Storage Instruction:
Store in a cool and dry place, protected from light & moisture.

Commercial Pack:
Each commercial pack contains 30 tablets in Alu-PVDC blister pack.

Manufactured by :
Orion Laboratories Limited