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A·MYCIN (Erythromycin) Is a macrolide antibiotic which may be bactericidal or bacteriostatic. Erythromycin binds to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis without affecting nucleic acid synthesis.
A·MYCIN (Erythromycin) is usually active against following organisms: Gram'positive : Staphylococcus aureus, Streptococcus pyogenlis, S. pneumoniae, Corynebacterium diphtheriae, C. minutissimum. Gram·negative,.,Moraxella catarrhalis, Neisseria gonormoeae, Leglonella pneumophlla, Bor1!litella pertussis. Mycoplasma :
Mycoplasma pnaumoniae, Ureoplasma urealytlcum. Others : Chlamydia tlachomatis, Entamoeba histolytica, Treponema paliidum, Listeria monocytogenes.
Composition:
A·MYCIN Tablet: Each enteric coated tablet contains Erythromycin BP 250 mg.
A·MYCIN • 500 Tablet: Each enteric coated tablet contains Erythromycin BP 500 mg.
A·MYCIN Powder for Suspension : After reconstitution each 5 ml suspension contains Erythromycin Ethylsuccinate USP equivalent to 125 mg of Erythromycin.
A·MYCIN OS Powder for Suspension : After reconstitution each 5 ml suspension contains Erythromycin Ethylsuccinate USP equivalent to 250 mg of Erythromycin.
A-MYCIN Paedletrlc Drops: After reconstitution each 5 ml suspension contains Erythromycin Ethylsuccinate USP equivalent to 200 mg of Erythromycin.
Indications:
A·MYCIN is highly effective in the treatment of a wide variety of clinical infections,such as
Upper respiratory tract infections:Tonsillitis, peritonaillar abscess,pharyngitis,larynigitis,sinusitis,secondary infections in colds and influenza.
Lower respiratory tract Infactlons: Tracheitis, acute and chronic bronchrtis.Mycoplasma pneumonia (lobar pneumonia, broncho pneumonia, primary atypical pneumonia), bronchiectasis.
Skin and soft tlasue Infectlona: Boils and cartluncles,paronychia, abscesses, pustular acne, impetigo, cellulrtis, furuncolosis, erythrasma.
Venereal Infections: Non-specific urethritis, syphilis (if the patient is allergic to penicillin)
Gastro-Intestinal Infections : Cholecystitis, Staphylococcal enterocolrtls, Infectious diarrhoea & cholera.
Ear and oral Infections: Otitis media and otitis externa, gingivitis, dental abscesses.
Prophylaxis: Pre-operative and post-operative, trauma, burns, rheumatic fever.
Other Intections: Diphtheria, whooping cough.
Dosages & Admlnlatratlon:
Adults: Usually 250 mg every 6 hours, or 500 mg every 12 hours. May increase up to 4 g/day, according to severrty of infeclion.
Infections with Dosages and Admlnlatratlon is Describe Bellow:
Uppar respiratory tract infactions :
250 to 500 mg 4 times a day for 10 days of mild to moderate severity
Lower respiratory tract infections:
250 to 500 mg 4 times a day for 10 days of mild to moderate severity
Respiratory tract lnfeclions due to Mycoplasma pneumoniae:
500 mg 6 hours for 5 to 10 days, treat severe infections for up to 3 weeks
Skin and soft tissue infections of mild to moderate severity:
250 to 500 mg 4 times a day for 10 days
Pelvic inflammatory diseases (PID), acute due to Neisseria gonorrhoeae:
500 mg 4 times a day for 10 to 14 days
Urogenital infaction during pregnancy caused by Chlamydia trachomatis:
500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days
Urethral, endocervical or rectal Infections, uncomplicated:
500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days
Non-gonococcal urethritis :
500 mg 4 times daily for at least 7 days
Neisseria gonorrhoeae: Uncomplicated urethral, endocervical or rectal infections end in panicillinase producing N. gonprrhoeae (PPNG):
Early syphillis (primary, secondary) or latent syphillis of <>
500 mg 4 times a day for 14 days
Severe or chronic diarrhoea:
500 mg 4 times a day for 7 days
Rheumatic fever:
250 mg 2 times dally
Bacterial endocarditis:
1 g 2 hours prior to procedures, then 500 mg 6 hours after initial dose
Acne:
500 mg twice daily for 3 months reduced to 250 mg twice daily for 3 months
Children: The usual oral dose is 30-50 mg/kg body weight par day in divided doses.For more severe infections, the dose may be doubled.
Adverse Effects:
Gastro-intestinal-abdominal cramp & discomfort, nausea, vomiting & diarrhoea. Hyparsensitivlty reaction may also be responsible for the hepatotoxicity sometimes in patients receiving A·MYCIN (Erythromycin) or its derivatives.
Precautions & Warnings:
All forms of A-MYCIN (Erythromycin) should be used with care in patients wrth existing hepatic impairment. It has been suggested that A·MYCIN (Erythromycin) should be used with care in patients with history of arrhythmias .
Drug Interactions:
A·MYCIN (Erythromycin) may decrease the clearance of theophylline causing increased theophylline serum level and potential toxicity. It may decrease the metabolism of carbamazepine, triazolam, hexobarbital and phenytoin causing increased serum levels and potential toxicity. A·MYCIN (Erythromycin) may decrease the clearance of warfarin and thus potentiate the hypoprothrombinic effect of warfarin.
Use In Pregnancy and lactation:
Erythromycin is a pregnancy category B drug. Erythromycin Is considered compatible with breast feeding by the American Academy of Paediatrics.
Contraindications:
A·MYCIN (Erythromycin) is contraindicated in patents wrth known hypersensrtivity of this antibiotic.
Storage:
Store In a cool, dry place & away from light. Keep out of the reach of children.
Packing:
A·MYCIN Tablet: Box containing 5x10'sl10x10's tablet in blister pack.
A·MYCIN - 500 Tablet: Box containing 3x10's/5x10's in tablet blister pack.
A·MYCIN Powder for Suspension : Bottle containing dry powder for reconstitution of 100 ml suspension.
A·MYCIN DS Powder for Suspension : Bottle containing dry powder for reconstitution of 50 m1/100 ml suspension.
A·MYCIN Paediatric Drops: Bottle containing dry powder for reconstitution of 25 ml/ 50 ml/ 60 ml suspension with droppar.
Manufactured by :
ARISTOPHARMA LTD.
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